I have seen a lot of prayer requests over the past few months from people recently laid off and looking for a job. For those looking for a job, I found this article, which attests to the intercessory power of St. Josemaría Escrivá.
St. Josemaría is the founder of Opus Dei and his main message is that we can be sanctified through our regular work – as a laborer, as a mother, as a computer programmer. He placed great value on a job well done, so I imagine a novena to him from those looking for a job could be pretty effective.
Here is a link to a suggested novena prayer (PDF-format).
St. Josemaría, pray for us!